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Sarilumab - Regeneron/Sanofi

Drug Profile

Sarilumab - Regeneron/Sanofi

Alternative Names: Anti-IL 6 receptor antibody; Anti-interleukin 6 receptor antibody; Kevzara; REGN-88; SAR-153191

Latest Information Update: 20 Sep 2021

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At a glance

  • Originator Regeneron Pharmaceuticals; sanofi-aventis
  • Developer Asahi Kasei Pharma Corp; Regeneron Pharmaceuticals; Sanofi
  • Class Anti-inflammatories; Antirheumatics; Antivirals; Monoclonal antibodies
  • Mechanism of Action Interleukin 6 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Rheumatoid arthritis
  • Phase II Juvenile rheumatoid arthritis
  • Discontinued Ankylosing spondylitis; COVID 2019 infections; Giant cell arteritis; Polymyalgia rheumatica; Uveitis

Most Recent Events

  • 20 Sep 2021 Regeneron Pharmaceuticals withdraws a phase I/II pilot study in Circumscribed-scleroderma in USA
  • 18 Aug 2021 Biomarkers information updated
  • 19 May 2021 Sanofi and Regeneron Pharmaceuticals discontinues phase III trial in Polymyalgia rheumatica in Argentina, Australia, Belgium, Canada, Estonia, France, Germany, Hungary, Israel, Italy, Japan, Netherlands, Russia, Spain, Switzerland, the UK and the US (SC, Injection) (NCT03600818) (EudraCT2017-002989-42)
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