Durvalumab- MedImmune

Drug Profile

Durvalumab- MedImmune

Alternative Names: Anti-PD-L1 monoclonal antibody; Anti-PD-LI mAb; Anti-programmed cell death 1 ligand 1 monoclonal antibody; Imfinzi; MEDI-4736

Latest Information Update: 01 Dec 2017

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At a glance

  • Originator MedImmune
  • Developer Advaxis; AstraZeneca; Canadian Cancer Trials Group; Case Comprehensive Cancer Center; Celgene International SARL; Centre Leon Berard; Childrens Hospital Los Angeles; Eli Lilly; Fondazione IRCCS Istituto Nazionale dei Tumori; GlaxoSmithKline; Gradalis; Grand Hopital de Charleroi; Grupo Espanol de Tumores Neuroendocrinos; Gustave Roussy; Immunocore; Institut Claudius Regaud; Juno Therapeutics; Kyoto Breast Cancer Research Network; Ludwig Institute for Cancer Research; M. D. Anderson Cancer Center; MedImmune; Memorial Sloan-Kettering Cancer Center; Mirati Therapeutics; National Cancer Institute (USA); National Health and Medical Research Council; Northwestern University; Pharmacyclics; Plexxikon; Samsung Medical Center; Seoul National University Hospital; Swiss Group for Clinical Cancer Research; University of Colorado at Denver; University of Maryland Greenbaum Cancer Center; University of Texas M. D. Anderson Cancer Center; VentiRx Pharmaceuticals; Washington University School of Medicine; Yale University
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CD274 antigen inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Urogenital cancer
  • Preregistration Non-small cell lung cancer
  • Phase III Head and neck cancer; Small cell lung cancer; Solid tumours
  • Phase II/III Breast cancer; Pancreatic cancer
  • Phase II Acute myeloid leukaemia; Biliary cancer; Brain metastases; Colorectal cancer; Diffuse large B cell lymphoma; Endometrial cancer; Fallopian tube cancer; Gastric cancer; Glioblastoma; Hepatocellular carcinoma; Mesothelioma; Multiple myeloma; Myelodysplastic syndromes; Neuroendocrine tumours; Oesophageal cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer; Sarcoma
  • Phase I/II Cervical cancer; Chronic lymphocytic leukaemia; Cutaneous T cell lymphoma; Lung cancer; Lymphoma; Malignant melanoma; Non-Hodgkin's lymphoma; Peripheral T-cell lymphoma; Soft tissue sarcoma
  • Phase I CNS cancer; Lymphoproliferative disorders; Myelofibrosis; Oropharyngeal cancer; Renal cell carcinoma; Thyroid cancer

Most Recent Events

  • 14 Nov 2017 AstraZeneca plans the phase II HUDSON trial for Non-small cell lung cancer (Combination therapy, Second-line therapy or greater, Metastatic disease) in USA, Austria, Canada, Germany and South Korea, in November 2017 (NCT03334617)
  • 13 Nov 2017 Eli Lilly and AstraZeneca terminates a phase Ia/Ib trial for Solid tumours (Combination therapy, Late-stage disease, Second-line therapy or greater) in USA (SC) (NCT02737072)
  • 07 Nov 2017 AstraZeneca plans a phase II trial for Pancreatic cancer (Adjuvant therapy) (NCT03038477)
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